Weight, height and lean mass are positive influences in bone mass in adolescents with HIV vertical transmission treated with HAART
A. Schtscherbyna1, C.H. Torres1, L.M.C. Mendonça2, C. Gouveia3, M.L.F. Farias1, E.S. Machado3
1Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Endocrinology, Rio de Janeiro, Brazil, 2Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Reumathology, Rio de Janeiro, Brazil, 3Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Infectious and Parasitic Diseases, Rio de Janeiro, Brazil
Background: variation in bone mass accumulation during childhood and adolescence may be an important determinant of the risk of sustaining osteoporotic fractures during later adulthood. The aim was to study a 1 year follow up of vertically HIV infected adolescents treated with HAART, analyzing correlation between bone mineral content and body composition.
Methods: the sample was composed of 34 patients (16 girls and 18 boys), aged from 13.9 to 19.4 yr at the baseline who were followed at an University Hospital in Rio de Janeiro, Brazil. Spine (L1-L4) and total body bone mineral content (sBMC and tbBMC), and body composition assessment were estimated by the method of dual-energy X-ray absorptiometry (Lunar Prodigy Advanced Plus, GE Lunar). Prodigy software developed for child and adolescent assessment was used. Weight was measured with Filizola platform mechanic scale (precision of 100 g), and height with a Personal Sanny stadiometer (precision of 1 mm). Pearson's coefficients of simple linear correlation between the variables of body composition and Z-score of BMC were calculated the level of significance adopted was lower than 5% (p< 0.05). All analyses were conducted with SPSS 13.0.
Results: spine BMC (Δ sBMC) was directly related to weight (r= 0.48, p= 0.004), height (r= 0.52, p= 0.002) and lean mass (r= 0.68, p= 0.000). Total body BMC (Δ tbBMC) was directly related to weight (r= 0.69, p= 0.000), height (r= 0.74, p= 0.000), BMI (r= 0.39, p= 0.022), and lean mass (r= 0.73, p= 0.000).
Conclusions: the gain of weight, height and lean mass are positive influences in the variation of the spine BMC and in total body BMC. Besides these, increases in BMI showed a direct correlation in the variation of total body BMC. All these teenagers will be monitored to attempt to improve the nutritional state and therefore low bone mass.
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