Epidemiological and clinical features of primary HIV-infection in a public hospital in Buenos Aires, Argentina
C. Acuipil1,2, E. Cordova1,2, E. Loiza1,2, N. Porteiro1,2, H. Mingrone1,2
1Infectious Diseases ´F. Muñiz´ Hospital, Outpatient Care Unit, Buenos Aires, Argentina, 2IDEAA Foundation, Buenos Aires, Argentina
Background: Although diagnosis of primary HIV-infection is a very rare situation, it has relevant implications for epidemiology and clinical practice. We aimed to analyze epidemiological and clinical findings of a cohort of primary HIV1-infected patients assisted at a public hospital in Argentina.
Methods: We retrospectively analyzed 85 patients assisted at the Outpatient Care Unit of “F.J.Muñiz” Hospital from 1998 to 2009 with diagnosis of acute or recent HIV infection.
Results: N=85. Male: 67 (78%). Age mean: 33 years (CI95% 30-36). Heterosexual: 53 (62%), MSM: 26 (30,5%), 3 (3,5%) UDI/Heterosexual and 3 (3.5%) unknown. Mean baseline CD4+T-cell count (cells/mm3): 483(CI95%421-544) with no differences between gender: male 475 (CI95% 399-550) and female 521 (CI95% 412-630) (p=0,5).Mean baseline viral load (VL): 4,5 log10 (CI95% 4,2-4,8) with higher values in males: 4,7 (CI95% 4,5-5) vs. 3,8 (CI95% 3,1-4,6), p=0,005. Symptomatic: 54 (63,5%). No differences in mean CD4+T-cell count between symptomatic [466/mm3(CI95% 389-543)] and asymptomatic patients [522/mm3 (CI95% 417-626)] (p=0,4). Symptomatic patients had higher mean VL: 4,7(CI95% 4,4-5) vs 4,1(CI 95% 3,5-4,7) (p=0,049). Patients with ≥ 3 symptoms had higher VL than those with < 3 symptoms : 5 (CI95% 4,7-5,3) vs. 4,3 (CI95% 3,7-4,8) (p=0,01). Abnormal laboratory findings were observed in 29 patients (34%) and no differences between those with no laboratory findings were found in mean CD4+T-cell count [465 (CI95% 436-552) vs 494 (CI 95% 331-559), p=0,6] or mean VL [4,8 (CI95% 4,5-5,2) vs 4,4 (CI95% 4-4,7), p=0,09]. Opportunistic infections were diagnosed in 7 (8,2%) patients and no mortality was found in this period.
Conclusions: Most of the patients in our cohort were middle age-men with sexually transmitted HIV infection. Male population, acute retroviral syndrome and patients with ≥ 3 symptoms had higher VL values. A low prevalence of opportunistic infections was observed.
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