XVIII International AIDS Conference

Abstract

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Initial versus current nutritional status of children attending a paediatric HIV reference centre in São Paulo, Brazil

L.F. Tanaka1, M.R.D.O. Latorre1, A.M. Silva1, T.C.R. Oliveira1, E.C. Mendes1, H.H.S. Marques2

1University of Sao Paulo, Epidemiology, São Paulo, Brazil, 2University of Sao Paulo, Instituto da Criança do Hospital das Clinicas, São Paulo, Brazil

Background: Poor growth is highly prevalent among HIV-infected. The aim of the present study was to compare initial and current nutritional status of HIV-infected children.
Methods: We carried out a retrospective study of HIV-infected children attending the Infectology Service of Children's Institute (CI), who had been diagnosed between 1992 and 2003. Data were obtained from hospital records. To be included in the analysis all patients should be alive in July 2009 and had been followed up for at least 5 years. Hundred children (51% females) were assessed. World Health Organization growth standards were used to classify children according to their nutritional status. Paired Student's t test was used to compare means.
Results: At admission, mean age was 2.3 years, weight 10.5 kg, length/height 79.1 cm. 42.0% presented stunting and 13.0% low BMI. Mean length/height-for-age and BMI-for-age Z-scores were -1.73 and -0.28, respectively. Age at HIV diagnosis was 2.5 years. At the last visit to CI, mean age was 13.3 years, weight 42.0 kg and height 145.6 cm. Mean time of follow up was 11.0 years. Currently 99% of patients are taking ARVT, stunting affected 19.0% of children and low BMI 6.0%. Mean height-for-age and BMI-for-age Z-scores were -1.0 and -0.2, respectively. There was a significant difference between initial and current height-for-age z-score (p< 0.001), however, patients still remained shorter than the reference population (Figure 1).

Initial and current length/height curves
[Initial and current length/height curves]


Conclusions: Our results demonstrate that after a prolonged follow up, patients improve their nutritional status; but, they were not able to attain optimal growth.


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