AIDS 2010 - Vienna 18-23 July 2010 - XVIII International AIDS Conference

Malignancies in PLHIV	WEAB01

Type:

Oral Abstract Session

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Location:

SR 3

Schedule:

11:00 - 12:30, 21.07.2010

Code:

WEAB01

Chairs:

Ismael Diallo, Burkina Faso
Dominique Costagliola, France

Presentations in this session:

11:00
WEAB0101
Abstract
Slides with audio The burden of cancer among HIV-infected persons in the U.S. population
Presented by Eric Engels, United States
M. Shiels¹, R. Pfeiffer¹, M. Gail¹, I. Hall², J. Li², A. Chaturvedi¹, K. Bhatia¹, T. Uldrick¹, R. Yarchoan¹, J. Goedert¹, E. Engels¹
¹National Cancer Institute, Rockville, United States, ²Centers for Disease Control and Prevention, Atlanta, United States

11:15
WEAB0102
Abstract
Slides with audio AIDS-related malignancies in teenagers horizontally infected with HIV-1 during infancy
Presented by Florentina Dumitrescu, Romania
A. Cupsa¹, F. Dumitrescu¹, I. Niculescu¹, L. Giubelan¹, A.C. Stoian¹, A. Romanescu², C. Iocu²
¹University of Medicine and Pharmacy, Infectious Diseases, Craiova, Romania, ²"Victor Babes" Clinical Hospital of Infectious Diseases and Pneumology, Craiova, Romania

11:30
WEAB0103
Abstract
Slides with audio Lack of regression of anal squamous intraepithelial lesions and anal HPV infection despite immune restoration under cART
Presented by Christophe Piketty, France
C. Piketty¹, A. Si-Mohamed¹, E. Lanoy², B. Cochand-Priollet³, S. Trabelsi², P.-M. Girard⁴, R. Tubiana⁵, L. Abramowitz⁶, E. Tartour¹, L. Weiss¹, D. Costagliola^2,5, and the Valparaiso Study Group
¹Hopital Européen Georges Pompidou, Paris, France, ²INSERM U943 - UPMC UMR S943, Paris, France, ³Hopital Lariboisiere, Paris, France, ⁴Hopital Saint Antoine, Paris, France, ⁵Hopital de La Pitie-Salpetriere, Paris, France, ⁶Hopital Bichat-Claude Bernard, Paris, France

11:45
WEAB0104
Abstract
Slides with audio CD4 count trajectories of HIV-infected women in North America with cervical cancer after initiating antiretroviral therapy
Presented by Alison G Abraham, United States
A.G. Abraham¹, S. Gange¹, Y. Jing¹, R. Bosch², J.T. Brooks³, R. Dubrow⁴, J. Eron⁵, K. Gebo⁶, M.J. Gill⁷, N. Hessol⁸, B. Hogg⁹, M. Kitahata¹⁰, M. Klein¹¹, R. Moore⁶, S. Rourke¹², M. Silverberg¹³, G. D'Souza¹, North American AIDS Cohort Collaboration on Research and Design
¹Johns Hopkins Bloomberg School of Public Health, Epidemiology, Baltimore, United States, ²Harvard University, Boston, United States, ³Centers for Disease Control and Prevention, Atlanta, United States, ⁴Yale University, New Haven, United States, ⁵University of North Carolina, Chapel Hill, United States, ⁶Johns Hopkins School of Medicine, Baltimore, United States, ⁷University of Calgary, Calgary, Canada, ⁸University of Califorinia at San Francisco, San Francisco, United States, ⁹BC Centre for Excellence in HIV/AIDS, Vancouver, Canada, ¹⁰University of Washington, Seattle, United States, ¹¹McGill University, Montreal, Canada, ¹²University of Toronto, Toronto, Canada, ¹³Kaiser Permanente Northern California, Oakland, United States

12:00
WEAB0105
Abstract
Slides with audio Earlier age at cancer diagnosis and increased incidence of non-AIDS defining cancers in patients with advanced HIV infection
Presented by Minh Ly Nguyen, United States
M.L. Nguyen¹, A. Sumbry², D. Reddy¹, K. Harvey¹, C. Gunthel¹, C. Tsui¹, D. Ziemer³, C. del Rio⁴, J.L. Young⁵
¹Emory University School of Medicine, Medicine, Atlanta, United States, ²Emory University School of Medicine, Medicine, Altanta, United States, ³Grady Health Systems, Atlanta, United States, ⁴Rollins School of Public Health, Emory University, Global Health, Atlanta, United States, ⁵Rollins School of Public Health, Emory University, Epidemiology, Atlanta, United States

Rapporteur report

Track B report by Andrew KAMBUGU

WEAB01 Malignancies in PLHIV

This session had presentations which showed the profile and pattern of malignancies that occurred in HIV infected persons in the US, France and in Romania. All these presentations highlighted the higher prevalence of non-AIDS defining malignancies and mainly linked to infectious etiology. Also the presentations showed there is no major effect of HAART in the occurrence malignancies. It is evident from these presentations that cancer screening should be implemented in HIV infected persons as standard of care to reduce cancer related morbidity.

WEAB0101 The burden of cancer among HIV infected in the US

Engels, et al presented the spectrum and pattern of malignancies among HIV infected persons in the US. Non AIDS malignancies are on the rise, even at higher D4 counts despite on HAART.

WEAB0102 AIDS related malignancies in teenagers horizontally infected with HIV during infancy.

Florentine Dumitrescu et al from Romania did a retrospective review of AIDS related malignancies from a cohort of teenagers between 2000 and 2009. 3.5% had AIDS defining malignancies with mean age of 15. 62% had NHL and the average time to develop neoplasia from HIV diagnosis is 6.3yrs. 12 patients died and mainly due to NHL.

WEAB0103 Lack of regression of anal squamous intraepithelial lesions and anal HPV infections despite immune restoration under cART.

Christopher Piketty et al from France presented the Valpraiso study. Anal cytology and HPV DNA testing were carried out in a cohort of 94 HIV+ MSM who initiated on HAART. This study showed there is no effect of ART on the incidence of HPV.

WEAB0104 CD4 count trajectories of HIV infected women in North America with cervical cancer after initiating ART.

Alison Abraham, et al from Johns Hopkins on behalf of NA-ACCORD presented the profile of women who developed invasive cervical cancer from a cohort of 110,000 HIV infected women enrolled in NA ACCORD IeDEA database. The study participants are from 13 cohorts in North America. This is nested case control study. Women who had lower CD4 counts had higher incidence of invasive cervical cancer and this was not associated with viral load levels.

WEAB0105 Earlier age at cancer diagnosis and increased incidence of non AIDS defining cancers n patients with advanced HIV.

Nguyen, et al from the US presented data from SEER registry from 6 cities in the US (Atlanta, Detroit, LA, San Francisco, San Jose and Seattle). This was a retrospective study conducted from the data collected between 2000 and 2007. 8300 patients were enrolled in this study and among this 512 patients had cancer diagnosis. 192 had Non AIDS malignancies and 320 had AIDS defining malignancies. Among Non AIDS malignancies, lung cancer and among AIDS defining Kaposi’s sarcoma was the most common one. High incidence of Non AIDS defining malignancies were reported in this cohort and it is linked to infectious etiology. Anal squamous cell carcinoma had a risk of 68 times in HIV infected population as compared to general population. This presentation concluded with a message that cancer screening should be implemented in HIV infected at an early age.